Primary Category:

Radiation Oncology

Disease Category:

Brain, Brain Metastatic


Temporarily Closed

A Phase III Trial of Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases

For CCTG CE.7, please credit ALLIANCE all accruals.


Enrollment of new patients to this study has been temporarily suspended effective immediately, 03/08/19, pending protocol amendment. Based on preliminary results of the NRG-CC001 study, presented at the 2018 Annual Meeting of the American Society for Radiation Oncology (ASTRO) and during the plenary session of the 2018 Annual Meeting of the Society for Neuro-Oncology (SNO), an amendment has been submitted to CTEP revising the WBRT control arm of the CE.7 trial to incorporate hippocampal avoidance. Accrual will resume upon approval and activation of the amendment.